HCWB / HCW Biologics Inc. - SEC Dosyaları, Yıllık Rapor, Vekil Beyanı

HCW Biologics Inc.

Temel İstatistikler
CIK 1828673
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to HCW Biologics Inc.
SEC Filings (Chronological Order)
Bu sayfa, başka bir yerde sunduğumuz mülkiyet başvuruları hariç, SEC Dosyalarının tam ve kronolojik bir listesini sunmaktadır.
June 1, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2026 HCW Biologics Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction (Commission (IRS Employer of Incorpor

May 27, 2026 EX-99.1

HCW Biologics Exercised Option to Regain Full Rights for Two Commercial-Ready Reagents from Wugen Positions the Company to participate in fast-growing, multi-billion-dollar CAR-T immunotherapy market Recently published data suggest that HCW9206 may r

EXHIBIT 99.1 HCW Biologics Exercised Option to Regain Full Rights for Two Commercial-Ready Reagents from Wugen Positions the Company to participate in fast-growing, multi-billion-dollar CAR-T immunotherapy market Recently published data suggest that HCW9206 may reduce CAR-T production costs and improve therapeutic efficacies, with the potential to support curative outcomes Company plans to commerc

May 27, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2026 HCW Biologics Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 21, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2026 HCW Biologics Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 21, 2026 EX-99.1

HCW Biologics Inc. Announces Pricing of Approximately $4.0 Million Private Placement Offering At-the-Market Under Nasdaq Rules

Exhibit 99.1 HCW Biologics Inc. Announces Pricing of Approximately $4.0 Million Private Placement Offering At-the-Market Under Nasdaq Rules MIRAMAR, Fla., May 21, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the “Company” or “HCW Biologics”), (NASDAQ: HCWB), a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat autoimmune, cancer and senescence-asso

May 21, 2026 EX-10.1

FORM OF SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is entered into and made effective as of May 21, 2026, by and among HCW Biologics Inc., a Delaware corporation (the “Company”), each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). RECITALS WHEREAS

May 21, 2026 EX-4.2

FORM OF COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC.

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 21, 2026 EX-10.2

FORM OF REGISTRATION RIGHTS AGREEMENT

Exhibt 10.2 FORM OF REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of May 21, 2026 between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser appearing on the signature page to the Purchase Agreement (as defined below) (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”). WHEREAS, the C

May 21, 2026 EX-10.3

FORM OF PLACEMENT AGENCY AGREEMENT

Exhibit 10.3 FORM OF PLACEMENT AGENCY AGREEMENT May 21, 2026 PERSONAL AND CONFIDENTIAL HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 Attention: Hing Wong, Ph.D., Chief Executive Officer Dear Dr. Wong: This agreement (the “Agreement”) constitutes the agreement between E.F. Hutton & Co. (the “Placement Agent”) on one hand, and HCW Biologics Inc., a Delaware corporation (the “Company”

May 21, 2026 EX-4.1

HCW BIOLOGICS INC.

Exhibit 4.1 HCW BIOLOGICS INC. NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO A

May 18, 2026 EX-10.38

FORM OF AMENDED AND RESTATED CONSULTING AGREEMENT

Exhibit 10.38 FORM OF AMENDED AND RESTATED CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to HCW Biologics Inc. (“you,” “Client” or “Company”) as more fully described in this amended and restated agreement (the “A&R Agreement”). This A&R Agreement supersedes the Consulting Agreement signed on April 25, 2026 (“Original Consulti

May 18, 2026 EX-1.1

FORM OF PLACEMENT AGENCY AGREEMENT

Exhibit 1.1 FORM OF PLACEMENT AGENCY AGREEMENT [●], 2026 PERSONAL AND CONFIDENTIAL HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 Attention: Hing Wong, Ph.D., Chief Executive Officer Dear Dr. Wong: This agreement (the “Agreement”) constitutes the agreement between E.F. Hutton & Co. (the “Placement Agent”) on one hand, and HCW Biologics Inc., a Delaware corporation (the “Company” and

May 18, 2026 POS AM

As filed with the Securities and Exchange Commission on May 18, 2026

As filed with the Securities and Exchange Commission on May 18, 2026 Registration No.

May 14, 2026 EX-99.1

HCW Biologics Reports First Quarter 2026 Business Highlights and Financial Results

EXHIBIT 99.1 HCW Biologics Reports First Quarter 2026 Business Highlights and Financial Results Miramar, FL – May 14, 2026 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on developing transformative fusion immunotherapeutics to treat autoimmune disease, cancer and senescence-associated dysplasia, today reported financial r

May 14, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2026 HCW Biologics Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 14, 2026 EX-10.40

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Exhibit 10.40 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

May 14, 2026 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW Biolo

May 13, 2026 POS AM

As filed with the Securities and Exchange Commission on May 13, 2026

As filed with the Securities and Exchange Commission on May 13, 2026 Registration No.

April 30, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2026 HCW Biologics Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 30, 2026 EX-10.1

CONSULTING AGREEMENT

Exhibit 10.1 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to HCW Biologics Inc (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) This

April 30, 2026 EX-10.2

CONSULTING SERVICES AGREEMENT THIS AGREEMENT DATED AS OF April 24, 2026 HCW Biologics Inc. A Delaware corporation headquartered in Miramar, Florida (hereinafter referred to as the “Firm”) Bowery Consulting Group Inc. A corporation registered in the S

Exhibit 10.2 CONSULTING SERVICES AGREEMENT THIS AGREEMENT DATED AS OF April 24, 2026 BETWEEN: HCW Biologics Inc. A Delaware corporation headquartered in Miramar, Florida (hereinafter referred to as the “Firm”) -and- Bowery Consulting Group Inc. A corporation registered in the State of Florida (hereinafter referred to as the “Consultant”) A. RECITALS WHEREAS the Firm carries on business as company

April 30, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2026 (April 27, 2026) H

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2026 (April 27, 2026) HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation)

April 30, 2026 EX-99.1

HCW Biologics Announces Adjournment of Special Meeting of Stockholders Due to Lack of Quorum

Exhibit 99.1 HCW Biologics Announces Adjournment of Special Meeting of Stockholders Due to Lack of Quorum MIRAMAR, Fla., April 30, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the “Company” or “HCW Biologics”), (NASDAQ: HCWB), a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation today announced t

April 28, 2026 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy Sta

April 28, 2026 ARS

ARS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) շ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ն TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40591 HCW Biologics I

April 24, 2026 S-1/A

As filed with the Securities and Exchange Commission on April 24, 2026

As filed with the Securities and Exchange Commission on April 24, 2026 Registration No.

April 23, 2026 EX-10.36

FORM OF LOCK-UP AGREEMENT

Exhibit 10.36 FORM OF LOCK-UP AGREEMENT [], 2026 HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 Re: Placement Agency Agreement, dated as of [], 2026 (the “Placement Agency Agreement”), between HCW Biologics Inc. (the “Company”) and E.F. Hutton & Co. (the “Placement Agent”). Ladies and Gentlemen: Defined terms not otherwise defined in this letter agreement (the “Letter Agreement”) sh

April 23, 2026 S-1

As filed with the Securities and Exchange Commission on April 23, 2026

As filed with the Securities and Exchange Commission on April 23, 2026 Registration No.

April 23, 2026 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-1 HCW Biologics Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial

April 23, 2026 EX-1.1

FORM OF PLACEMENT AGENCY AGREEMENT

Exhibit 1.1 FORM OF PLACEMENT AGENCY AGREEMENT [●], 2026 PERSONAL AND CONFIDENTIAL HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 Attention: Hing Wong, Ph.D., Chief Executive Officer Dear Dr. Wong: This agreement (the “Agreement”) constitutes the agreement between E.F. Hutton & Co. (the “Placement Agent”) on one hand, and HCW Biologics Inc., a Delaware corporation (the “Company” and

April 23, 2026 EX-4.7

HCW BIOLOGICS INC. FORM OF PRE-FUNDED WARRANT

Exhibit 4.7 HCW BIOLOGICS INC. FORM OF PRE-FUNDED WARRANT Warrant Shares: [ ] Initial Exercise Date: [], 2026 Issue Date: [], 2026 THIS PRE-FUNDED WARRANT (the “Warrant”) certifies that, for value received, [] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “I

April 23, 2026 EX-10.35

FORM OF SECURITIES PURCHASE AGREEMENT

Exhibit 10.35 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of [*], 2026, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser,” and collectively, the “Purchasers”). WHEREAS, subject to the terms and condition

April 17, 2026 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Sta

April 16, 2026 EX-3.2A

AMENDMENT TO AMENDED AND RESTATED BYLAWS HCW BIOLOGICS INC.

Exhibit 3.2a AMENDMENT TO AMENDED AND RESTATED BYLAWS OF HCW BIOLOGICS INC. This Amendment (the “Amendment”) to the Amended and Restated Bylaws of HCW Biologics inc., a Delaware corporation (the “Corporation”), shall be, and hereby is, adopted and effective upon the unanimous written consent of the Board of Directors of the Corporation (the “Board”), approving this Amendment. WHEREAS, the Corporat

April 16, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2026 HCW Biologics Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 13, 2026 DRS

As confidentially submitted to the U.S. Securities and Exchange Commission on April 10, 2026. This draft registration statement has not been publicly filed with the U.S. Securities and Exchange Commission and all information herein remains strictly c

As confidentially submitted to the U.S. Securities and Exchange Commission on April 10, 2026. This draft registration statement has not been publicly filed with the U.S. Securities and Exchange Commission and all information herein remains strictly confidential. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE S

March 31, 2026 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 31, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

March 31, 2026 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40591 HCW Biologics I

March 31, 2026 EX-10.36

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Exhibit 10.36 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definiti

March 31, 2026 EX-10.35

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Exhibit 10.35 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definiti

March 31, 2026 EX-19.1

HCW BIOLOGICS INC. INSIDER TRADING POLICY (Adopted and approved on June 10, 2021 and as amended through March 28, 2023)

Exhibit 19.1 HCW BIOLOGICS INC. INSIDER TRADING POLICY (Adopted and approved on June 10, 2021 and as amended through March 28, 2023) 1. Purpose The following sets forth the policy of HCW Biologics Inc. (the “Company”) with respect to transactions in the Company’s securities (e.g., common stock), as well as the securities of publicly-traded companies with which the Company has a business relationsh

March 31, 2026 EX-99.1

HCW Biologics Reports Fourth Quarter 2025 and Fiscal Year 2025 Business Highlights and Financial Results

EXHIBIT 99.1 HCW Biologics Reports Fourth Quarter 2025 and Fiscal Year 2025 Business Highlights and Financial Results Miramar, FL – March 31, 2026 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation, today reported financia

March 17, 2026 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

March 17, 2026 EX-99.1

HCW Biologics Closes Exclusive Worldwide License for HCW11-006 – A High Potential Fusion Immunotherapeutic Upfront cash fee with total value of $7.0 million, comprised of a $3.5 million cash payment and $3.5 million in-kind payment in the form of a t

Exhibit 99.1 HCW Biologics Closes Exclusive Worldwide License for HCW11-006 – A High Potential Fusion Immunotherapeutic Upfront cash fee with total value of $7.0 million, comprised of a $3.5 million cash payment and $3.5 million in-kind payment in the form of a transferable equity interest in licensee Initiation of Phase 1 clinical study in China by licensee expected in the first half of 2027 HCW

March 13, 2026 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy Sta

March 3, 2026 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Sta

March 2, 2026 8-K

FORM 8-K Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 26, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

March 2, 2026 EX-99.1

HCW Biologics Regains Compliance with All Continued Listing Rules for Nasdaq Per Nasdaq Determination Letter

Exhibit 99.1 HCW Biologics Regains Compliance with All Continued Listing Rules for Nasdaq Per Nasdaq Determination Letter Miramar, FL – March 2, 2026 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (Nasdaq: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and dise

February 19, 2026 EX-4.2

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT hcw biologics inc.

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT hcw biologics inc. Warrant Shares: Initial Exercise Date: February 19, 2026 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date h

February 19, 2026 EX-99.1

HCW Biologics Announces Pricing of $1.5 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules

Exhibit 99.1 HCW Biologics Announces Pricing of $1.5 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules MIRAMAR, Fla., February 17, 2026 (GLOBE NEWSWIRE) - HCW Biologics Inc. (the “Company”), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing innovative immunotherapies to extend health span by targeting the link between chron

February 19, 2026 EX-10.3

[Signature Page Follows]

February 17, 2026 Holder of Warrants to Purchase Common Stock issued on November 20, 2025 Re: Amendment to Existing Warrants Dear Holder: Reference is hereby made to the offering on Form S-1 (File No.

February 19, 2026 EX-4.1

FORM OF COMMON STOCK PURCHASE WARRANT hcw biologics inc.

FORM OF COMMON STOCK PURCHASE WARRANT hcw biologics inc. Warrant Shares: Issue Date: February 19, 2026 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, . or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date that the Shareholder Approval (a

February 19, 2026 EX-10.1

FORM OF PLACEMENT AGENCY AGREEMENT February 17, 2026

FORM OF PLACEMENT AGENCY AGREEMENT February 17, 2026 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), HCW Biologics Inc.

February 19, 2026 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement. Item 7.01 Regulation FD Disclosure. Item 8.01 Other Events. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 17, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

February 19, 2026 EX-10.2

“Acquiring Person” shall have the meaning ascribed to such term in Section 4.5. (a) The obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met:

FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of February 17, 2026, between HCW Biologics Inc.

February 19, 2026 424B4

2,477,292 Units, each consisting of: One Share of Common Stock or One Pre-Funded Warrant to Purchase One Share of Common Stock and One Common Stock Warrant to Purchase One Share of Common Stock Up to 2,477,292 Shares of Common Stock or Shares of Comm

424B4 Table of Contents Filed pursuant to Rule 424(b)(4) Registration Statement No.

February 17, 2026 EX-23.1(A)

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1(a) Exhibit 23.1a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2024 (except for Note 16, as to which the date is March 28, 2025), with respect to the financial statements of HCW Biologics Inc. included in the Annual Report on Form 10-K for the year ended December 31, 2024, which are incorporated by reference in this Registration Statement.

February 17, 2026 EX-10.41

FORM OF SECURITIES PURCHASE AGREEMENT

EX-10.41 EXHIBIT 10.41 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of [ ], 2026, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and co

February 17, 2026 EX-4.5

FORM OF COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares: _______ Issue Date: _________

EX-4.5 Exhibit 4.5 FORM OF COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares: Issue Date: THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date that the Shareholder Approval (as

February 17, 2026 EX-23.1(B)

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1(b) Exhibit 23.1b CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement of HCW Biologics Inc. on Form S-1 of our report dated March 28, 2025 on the balance sheet of HCW Biologics Inc. as of December 31, 2024 and the statements of operations, stockholders’ equity (deficit) and cash flows for the year ended, and to

February 17, 2026 EX-1.1

FORM OF PLACEMENT AGENCY AGREEMENT

EX-1.1 EXHIBIT 1.1 FORM OF PLACEMENT AGENCY AGREEMENT      [ ], 2026 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), HCW Biologics Inc., a Delaware corporation (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of $[ ] of units, each unit consisting of (1) eit

February 17, 2026 S-1/A

As filed with the Securities and Exchange Commission on February 17, 2026

S-1/A Table of Contents As filed with the Securities and Exchange Commission on February 17, 2026 Registration No.

February 17, 2026 EX-FILING FEES

Calculation of Filing Fee Tables S-1 HCW Biologics Inc. Table 1: Newly Registered and Carry Forward Securities ☐ Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price

Calculation of Filing Fee Tables S-1 HCW Biologics Inc. Table 1: Newly Registered and Carry Forward Securities ☐ Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial

February 13, 2026 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 12, 2026 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

February 13, 2026 EX-99.1

HCW Biologics and WY Biotech Announce Closing of First Round of Financing For Newly Formed Joint Venture Trimmune HCW Biologics receiving cash fee and co-founder shares in Trimmune valued at $7.0 million Trimmune will hold exclusive worldwide license

Exhibit 99.1 HCW Biologics and WY Biotech Announce Closing of First Round of Financing For Newly Formed Joint Venture Trimmune HCW Biologics receiving cash fee and co-founder shares in Trimmune valued at $7.0 million Trimmune will hold exclusive worldwide license for rights to high potential preclinical molecule created with HCW Biologics’ TRBC drug development platform Initiation of Phase 1 clini

February 13, 2026 S-1/A

As filed with the Securities and Exchange Commission on February 13, 2026

S-1/A As filed with the Securities and Exchange Commission on February 13, 2026 Registration No.

February 11, 2026 CORRESP

February 11, 2026

CORRESP February 11, 2026 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: HCW BIOLOGICS Inc. Registration Statement on Form S-1 File No. 333-293396 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations of the U.S. Securities and Exchange Commission under the Securities Act of 1933, as amended,

February 11, 2026 EX-10.42

FORM OF LOCK-UP AGREEMENT

EX-10.42 EXHIBIT 10.42 FORM OF LOCK-UP AGREEMENT        , 2026 Re: Securities Purchase Agreement, dated as of       , 2026 (the “Purchase Agreement”), between HCW Biologics Inc. (the “Company”) and the purchasers signatory thereto (each, a “Purchaser” and, collectively, the “Purchasers”) Ladies and Gentlemen: Defined terms not otherwise defined in this letter agreement (the “Letter Agreement”) sha

February 11, 2026 EX-23.1(B)

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1(b) Exhibit 23.1b CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement of HCW Biologics Inc. on Form S-1 of our report dated March 28, 2025 on the balance sheet of HCW Biologics Inc. as of December 31, 2024 and the statements of operations, stockholders’ equity (deficit) and cash flows for the year ended, and to

February 11, 2026 EX-99.1

CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.1 Exhibit 99.1 CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Audit Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to: 1.1.1 Oversee the accounting and financial

February 11, 2026 CORRESP

February 11, 2026

CORRESP February 11, 2026 VIA EDGAR AND E-MAIL Mr. James McNamara Office of Life Sciences Division of Corporate Finance U.S. Securities and Exchange Commission 100 F. Street, N.E. Washington, DC 20549-7010 Re: HCW Biologics Inc. Registration Statement on Form S-1; Commission File No. 333-293396 Dear Mr. McNamara: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, HCW Bi

February 11, 2026 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-1 HCW Biologics Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial

February 11, 2026 EX-99.3

HCW BIOLOGICS INC. RELATED PARTY TRANSACTIONS POLICY (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.3 Exhibit 99.3 HCW BIOLOGICS INC. RELATED PARTY TRANSACTIONS POLICY (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose HCW Biologics Inc. (collectively with its subsidiaries, the “Company”) is committed to promoting high standards of ethical business conduct and compliance with applicable laws, rules and regulations. As part of this c

February 11, 2026 EX-10.43

AMENDMENT 1 TO AMENDED & RESTATED LICENSE, RESEARCH, AND CO-DEVELOPMENT AGREEMENT

EX-10.43 CERTAIN INFORMATION HAS BEEN REDACTED FROM THIS EXHIBIT IN ACCORDANCE WITH ITEM 601(B)(10)(IV) OF REGULATION S-K BECAUSE SUCH INFORMATION (1) IS NOT MATERIAL AND (2) IS THE TYPE OF INFORMATION THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. INFORMATION THAT HAS BEEN SO REDACTED FROM THIS EXHIBIT IS MARKED AS FOLLOWS: “[***]” TO INDICATE THE OMISSION Exhibit 10.43 AMENDMENT 1 TO AMENDED

February 11, 2026 EX-4.4

FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares: [  ] Initial Exercise Date: [  ], 2026

EX-4.4 EXHIBIT 4.4 FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares: [  ] Initial Exercise Date: [  ], 2026 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, [ ] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time o

February 11, 2026 EX-99.2

CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.2 Exhibit 99.2 CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to assist the Board in dischargin

February 11, 2026 EX-23.1(A)

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1(a) Exhibit 23.1a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2024 (except for Note 16, as to which the date is March 28, 2025), with respect to the financial statements of HCW Biologics Inc. included in the Annual Report on Form 10-K for the year ended December 31, 2024, which are incorporated by reference in this Registration Statement.

February 11, 2026 S-1

As filed with the Securities and Exchange Commission on February 11, 2026

S-1 Table of Contents As filed with the Securities and Exchange Commission on February 11, 2026 Registration No.

February 11, 2026 EX-10.40

AMENDED & RESTATED LICENSE, RESEARCH, AND CO-DEVELOPMENT AGREEMENT

EX-10.40 EXHIBIT 10.40 CERTAIN INFORMATION HAS BEEN REDACTED FROM THIS EXHIBIT IN ACCORDANCE WITH ITEM 601(B)(10)(IV) OF REGULATION S-K BECAUSE SUCH INFORMATION (1) IS NOT MATERIAL AND (2) IS THE TYPE OF INFORMATION THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. INFORMATION THAT HAS BEEN SO REDACTED FROM THIS EXHIBIT IS MARKED AS FOLLOWS: “[***]” TO INDICATE THE OMISSION. AMENDED & RESTATED LIC

February 11, 2026 EX-10.41

FORM OF SECURITIES PURCHASE AGREEMENT

EX-10.41 EXHIBIT 10.41 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of [ ], 2026, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and co

February 11, 2026 EX-10.44

北京源维 生物科技有限公司 Beijing ViGen Biotech Co. Ltd Shareholders’ Agreement

EX-10.44 CERTAIN INFORMATION HAS BEEN REDACTED FROM THIS EXHIBIT IN ACCORDANCE WITH ITEM 601(B)(10)(IV) OF REGULATION S-K BECAUSE SUCH INFORMATION (1) IS NOT MATERIAL AND (2) IS THE TYPE OF INFORMATION THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. INFORMATION THAT HAS BEEN SO REDACTED FROM THIS EXHIBIT IS MARKED AS FOLLOWS: “[***]” TO INDICATE THE OMISSION EXHIBIT 10.44 北京源维 生物科技有限公司 Beijing V

February 11, 2026 EX-1.1

FORM OF PLACEMENT AGENCY AGREEMENT

EX-1.1 EXHIBIT 1.1 FORM OF PLACEMENT AGENCY AGREEMENT      [ ], 2026 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), HCW Biologics Inc., a Delaware corporation (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of $[ ] shares (each a “Share” and collectively,

January 9, 2026 EX-23.1B

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1b Exhibit 23.1b CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement of HCW Biologics Inc. on Form S-1 of our report dated March 28, 2025 on the balance sheet of HCW Biologics Inc. as of December 31, 2024 and the statements of operations, changes in stockholders’ equity (deficit) and cash flows for the year ende

January 9, 2026 EX-99.3

HCW BIOLOGICS INC. RELATED PARTY TRANSACTIONS POLICY (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.3 Exhibit 99.3 HCW BIOLOGICS INC. RELATED PARTY TRANSACTIONS POLICY (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose HCW Biologics Inc. (collectively with its subsidiaries, the “Company”) is committed to promoting high standards of ethical business conduct and compliance with applicable laws, rules and regulations. As part of this c

January 9, 2026 EX-99.2

CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.2 Exhibit 99.2 CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to assist the Board in dischargin

January 9, 2026 EX-23.1A

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

EX-23.1a Exhibit 23.1a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2024 (except for Note 16, as to which the date is March 28, 2025), with respect to the financial statements of HCW Biologics Inc. included in the Annual Report on Form 10-K for the year ended December 31, 2024, which are incorporated by reference in this Registration Statement. W

January 9, 2026 EX-99.1

CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering)

EX-99.1 Exhibit 99.1 CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Audit Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to: 1.1.1 Oversee the accounting and financial

January 9, 2026 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-1 HCW Biologics Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial

January 9, 2026 S-1

As filed with the Securities and Exchange Commission on January 9, 2026

S-1 Table of Contents As filed with the Securities and Exchange Commission on January 9, 2026 Registration No.

December 31, 2025 8-K

FORM 8-K Item 8.01 Other Events.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 30, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

December 19, 2025 DRS

Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83

DRS Table of Contents Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83 Registration No. 333-    UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Jurisdict

November 20, 2025 EX-99.1

HCW Biologics Enters into $4.0 Million Warrant Inducement Priced At-the-Market Under Nasdaq Rules

EXHIBIT 99.1 HCW Biologics Enters into $4.0 Million Warrant Inducement Priced At-the-Market Under Nasdaq Rules MIRAMAR, Fla., Nov. 19, 2025 (GLOBE NEWSWIRE) - HCW Biologics Inc. (“HCWB” or the “Company”) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing innovative immunotherapies to extend health span by targeting the link between chronic i

November 20, 2025 EX-10.1

HCW Biologics Inc.

EXHIBIT 10.1 HCW Biologics Inc. November 19, 2025 Holder of Common Stock Purchase Warrants originally issued on November 20, 2024 and May 15, 2025 Re: Inducement Offer to Exercise Common Stock Purchase Warrants Dear Holder: HCW Biologics Inc. (the “Company”) is pleased to offer to you the opportunity to exercise all of the warrants to purchase shares of the Company’s common stock, par value $0.000

November 20, 2025 EX-4.1

(Signature Page Follows)

EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

November 20, 2025 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement. Item 3.02 Unregistered Sales of Equity Securities. Item 7.01 Regulation FD Disclosure. Item 8.01 Other Events. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 19, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 19, 2025 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 18, 2025 EX-99.1

HCW Biologics Announces Initiation of First-In-Human Clinical Trial to Evaluate HCW9302 in an Autoimmune Disease First Patient Dosed at The Ohio State University Wexner Medical Center in this Multi-Center Trial Active component of HCW9302 is interleu

EXHIBIT 99.1 HCW Biologics Announces Initiation of First-In-Human Clinical Trial to Evaluate HCW9302 in an Autoimmune Disease First Patient Dosed at The Ohio State University Wexner Medical Center in this Multi-Center Trial Active component of HCW9302 is interleukin-2 - cytokine that maintains proper numbers and functions of regulatory T cells to control excessive inflammation Gateway to developme

November 18, 2025 8-K

FORM 8-K Item 7.01 Regulation FD Disclosure. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 14, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 14, 2025 EX-99.1

HCW Biologics Reports Third Quarter 2025 Business Highlights and Financial Results

EXHIBIT 99.1 HCW Biologics Reports Third Quarter 2025 Business Highlights and Financial Results Miramar, FL – November 14, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and diseases, today reported f

November 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW B

October 16, 2025 8-K

FORM 8-K Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fil

October 1, 2025 DRS

Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83

DRS Table of Contents Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83 Registration No. 333-      UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Jurisdi

September 5, 2025 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 02, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission F

August 19, 2025 8-K

FORM 8-K Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 19, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

August 18, 2025 8-K/A

FORM 8-K/A Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

August 18, 2025 EX-10.16

Second Letter Agreement to the License, Research and Co-Development Agreement, dated July 13, 2025, between Company and WY Biotech Co. Ltd.

Exhibit 10.16

August 18, 2025 EX-10.13

Form of Common Stock Warrant, dated May 7, 2025, between Company and Holder

Exhibit 10.13 FORM OF COMMON STOCK PURCHASE WARRANT MAY 7, 2025 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFF

August 18, 2025 EX-99.1

HCW Biologics Reports Second Quarter 2025 Business Highlights and Financial Results

Exhibit 99.1 HCW Biologics Reports Second Quarter 2025 Business Highlights and Financial Results Correction Miramar, FL – August 18, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related dis

August 18, 2025 EX-10.14

Letter Agreement to the License, Research and Co-Development Agreement, dated March 17, 2025, between Company and WY Biotech Co. Ltd.

Exhibit 10.14

August 18, 2025 EX-10.17

Exclusive License Agreement 12-month Suspension, dated May 29, 2025, between the Company and Wugen, Inc.

Exhibit 10.17 May 29, 2025 Exclusive License Agreement 12-month Suspension HCW Biologics Inc. (“HCW”) and Wugen, Inc. (“Wugen”) hereby mutually agree to a 12-month suspension (herein “12-month Suspension”) of Wugen’s obligations under the Exclusive License Agreement (“License”) dated December 24, 2020, between HCW and Wugen. Wugen and HCW agree to maintain the License for the 12-month Suspension p

August 18, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW Biolog

August 18, 2025 EX-10.15

Confirmation of Letter of Acceptance of Deliverable from Company by WY Biotech Co. Ltd., dated May 30, 2025

Exhibit 10.15

August 18, 2025 EX-10.12

Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements, dated May 1, 2025, between Company and Holder

Exhibit 10.12 HCW BIOLOGICS INC. SECOND AMENDMENT TO AmendED AND RESTATED SENIOR SECURED NOTE PURCHASE AGREEMENT and related agreements This Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements (this “Second Amendment”) is made as of April , 2025 (the “Effective Date”) by and between HCW Biologics Inc., a Delaware corporation (the “Company”), and e

August 15, 2025 EX-10.1

First Amendment to Equity Purchase Agreement, dated August 14, 2025, between the Company and Square Gate Capital Master Fund, LLC- Series 4

Exhibit 10.1 FIRST AMENDMENT TO EQUITY PURCHASE AGREEMENT This FIRST AMENDMENT TO EQUITY PURCHASE AGREEMENT (this “First Amendment”) is made and entered into as of the 14th day of August, 2025 (the “Amendment Effective Date”) by and between HCW Biologics Inc., a Delaware corporation with a principal place of business at 2929 North Commerce Parkway, Miramar, FL 33025 (the “Company”) and Square Gate

August 15, 2025 8-K

FORM 8-K Item 1.01 Entry into a Material Definitive Agreement. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

August 15, 2025 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One):  ☐  Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: June 30, 2025 ☐ Tra

NT 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One):  ☐  Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: June 30, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-K For the Transit

August 14, 2025 EX-99.1

HCW Biologics Reports Second Quarter 2025 Business Highlights and Financial Results

Exhibit 99.1 HCW Biologics Reports Second Quarter 2025 Business Highlights and Financial Results Miramar, FL – August 14, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related diseases, toda

August 14, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

July 18, 2025 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

July 1, 2025 8-K

FORM 8-K Item 8.01 Other Events.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 26, 2025 EX-99.1

HCW Biologics Regains Compliance with Nasdaq Capital Market Requirements Company in full compliance for continued listing

Exhibit 99.1 HCW Biologics Regains Compliance with Nasdaq Capital Market Requirements Company in full compliance for continued listing  Miramar, FL – June 26, 2025 – HCW Biologics Inc. (“HCWB” or the “Company”) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing innovative immunotherapies to extend healthspan by targeting the link between ch

June 26, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 26, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 23, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 23, 2025 EX-99.1

June 23, 2025

Exhibit 99.1 June 23, 2025 Dear Stockholder, We would like to inform you that, after the conclusion of our Annual Stockholder Meeting, our provider, Broadridge Financial Solutions Inc., advised us that it had encountered technical difficulties during the live webcast of our Meeting on June 17, 2025. Unfortunately, their issue prevented some of you from logging in and participating as we had intend

June 13, 2025 8-K

FORM 8-K Item 8.01 Other Events.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 5, 2025 EX-99.1

HCW Biologics Announces Pricing of $5.0 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules

Exhibit 99.1 HCW Biologics Announces Pricing of $5.0 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules MIRAMAR, Fla., May 13, 2025 (GLOBE NEWSWIRE) - HCW Biologics Inc. (the “Company”), (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-re

June 5, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 05, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 5, 2025 EX-99.2

HCW Biologics Completes Deliverable and Solidifies License Agreement with WY Biotech HCW Biologics earned upfront payment and will recognize revenue of $7.0 million in Q2 2025

Exhibit 99.2 HCW Biologics Completes Deliverable and Solidifies License Agreement with WY Biotech HCW Biologics earned upfront payment and will recognize revenue of $7.0 million in Q2 2025 MIRAMAR, Fla., June 4, 2025 (GLOBE NEWSWIRE) - HCW Biologics Inc. (“HCWB” or “HCW Biologics”), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing novel im

June 4, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

June 4, 2025 EX-99.1

HCW Biologics Completes Deliverable and Solidifies License Agreement with WY Biotech HCW Biologics earned upfront payment and will recognize revenue of $7.0 million in Q2 2025

Exhibit 99.1 HCW Biologics Completes Deliverable and Solidifies License Agreement with WY Biotech HCW Biologics earned upfront payment and will recognize revenue of $7.0 million in Q2 2025 MIRAMAR, Fla., June 4, 2025 (GLOBE NEWSWIRE) - HCW Biologics Inc. (“HCWB” or “HCW Biologics”), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing novel im

May 30, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 23, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 21, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 20, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 15, 2025 EX-10.4

Form of Promissory Note, dated May 8, 2025, between the Company and Holder

Exhibit 10.4 THE SECURITIES REFERENCED HEREIN HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMP

May 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW Biolo

May 15, 2025 EX-10.3

Amendment to Existing Warrants Agreement, dated May 13, 2025, between the Company and Purchaser

Exhibit 10.3 May 13, 2025 Holder of Warrants to Purchase Common Stock issued on November 20, 2024 Re: Amendment to Existing Warrants Dear Holder: Reference is hereby made to the offering on Form S-1 (File No. 333-287136) on or about the date hereof (the “Offering”) by HCW Biologics Inc. (the “Company”) of common shares, par value $0.0001 per share (the “Common Shares”), and/or other securities of

May 15, 2025 EX-4.1

Form of Common Stock Purchase Warrant

Exhibit 4.1 FORM OF COMMON STOCK PURCHASE WARRANT hcw biologics inc. Warrant Shares: Initial Exercise Date: May 15, 2025 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Ini

May 15, 2025 EX-4.2

Form of Pre-Funded Common Stock Purchase Warrant

Exhibit 4.2 FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT hcw biologics inc. Warrant Shares: Initial Exercise Date: THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof

May 15, 2025 EX-10.1

Form of Placement Agency Agreement, dated May 13, 2025, between Company and Maxim Group LLC

Exhibit 10.1 FORM OF PLACEMENT AGENCY AGREEMENT May 13, 2025 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), HCW Biologics Inc., a Delaware corporation (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of $4,999,993 of units, each unit consisting of (1) eithe

May 15, 2025 424B4

PROSPECTUS 671,140 Units, each consisting of: One Share of Common Stock or One Pre-Funded Warrant to Purchase One Share of Common Stock and Two Common Stock Warrants each to Purchase up to One Share of Common Stock 671,140 Shares of Common Stock or S

Table of Contents Filed pursuant to Rule 424(b)(4) Registration Statement No. 333-287136 PROSPECTUS 671,140 Units, each consisting of: One Share of Common Stock or One Pre-Funded Warrant to Purchase One Share of Common Stock and Two Common Stock Warrants each to Purchase up to One Share of Common Stock 671,140 Shares of Common Stock or Shares of Common Stock Underlying Pre-Funded Warrants 1,342,28

May 15, 2025 EX-10.6

Form of Unsecured Convertible Promissory Note, dated May 5, 2025, between the Company and Holder

EXHIBIT 10.6 THE SECURITIES REFERENCED HEREIN HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMP

May 15, 2025 EX-99.1

HCW Biologics Reports First Quarter 2025 Business Highlights and Financial Results

Exhibit 99.1 HCW Biologics Reports First Quarter 2025 Business Highlights and Financial Results Miramar, FL – May 15, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related diseases, today re

May 15, 2025 EX-99.1

HCW Biologics Announces Pricing of $5.0 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules

Exhibit 99.1 HCW Biologics Announces Pricing of $5.0 Million Follow-On Offering Priced At-The-Market Under NASDAQ Rules MIRAMAR, Fla., May 13, 2025 (GLOBE NEWSWIRE) - HCW Biologics Inc. (the “Company”), (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-re

May 15, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 15, 2025 EX-10.2

Form of Securities Purchase Agreement, dated May 13, 2025, between the Company and Purchaser

Exhibit 10.2 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of May 13, 2025, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condition

May 15, 2025 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 15, 2025 EX-4.3

Form of amended and restated Common Stock Purchase Warrant

Exhibit 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 15, 2025 EX-10.5

Form of Guaranty and Pledge Agreement, dated May 8, 2025, between the Dr. Hing C. Wong and Lender

Exhibit 10.5 FORM OF GUARANTY AND PLEDGE AGREEMENT HCW BIOLOGICS INC., a Delaware corporation (the “Company”), is issuing that certain Promissory Note of even date herewith in the principal amount of $150,000 to [***] (the “Lender”) to memorialize the loan in such principal amount being funded by Lender to the Company on the date hereof (the “Loan”). RECITALS: WHEREAS, dr. hing c. wong (“Guarantor

May 13, 2025 S-1/A

As filed with the U.S. Securities and Exchange Commission on May 13, 2025

As filed with the U.S. Securities and Exchange Commission on May 13, 2025 Registration No. 333-287136 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Pre-Effective Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Jurisdiction

May 13, 2025 CORRESP

VIA EDGAR

May 13, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: HCWB Biologics Inc. Registration Statement on Form S-1 File No. 333-287136 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations of the U.S. Securities and Exchange Commission under the Securities Act of 1933, as amended, Maxim Group

May 9, 2025 EX-23.1B

Consent of Independent Registered Public Accounting Firm (Crowe Successor)

EX-23.1B Exhibit 23.1b CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement of HCW Biologics Inc. on Form S-1 of our report dated March 28, 2025 on the balance sheet of HCW Biologics Inc. as of December 31, 2024 and the statements of operations, stockholders’ equity (deficit) and cash flows for the year then ended, and

May 9, 2025 CORRESP

May 9, 2025

CORRESP 1 filename1.htm May 9, 2025 VIA EDGAR AND E-MAIL Mr. Jason Drory Office of Life Sciences Division of Corporate Finance U.S. Securities and Exchange Commission 100 F. Street, N.E. Washington, DC 20549-7010 Re: HCW Biologics Inc. Registration Statement on Form S-1; Commission File No. 333-287136 Dear Mr. Drory: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, HC

May 9, 2025 EX-4.7

Form of Warrant Agency Agreement

Exhibit 4.7 HCW BIOLOGICS INC. and EQUINITI TRUST COMPANY, LLC as Warrant Agent Form of Warrant Agency Agreement Dated as of , 2025 FORM OF WARRANT AGENCY AGREEMENT WARRANT AGENCY AGREEMENT, dated as of , 2025 (“Agreement”), between HCW Biologics Inc., a Delaware corporation (the “Company”), and Equiniti Trust Company, LLC (the “Warrant Agent”). W I T N E S S E T H WHEREAS, pursuant to a registere

May 9, 2025 S-1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Juri

S-1 Table of Contents Registration No. 333-      UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Jurisdiction of Incorporation or Organization) Primary Standard Industrial Classification Code Numb

May 9, 2025 EX-99.3

HCW Biologics Inc. Related Party Transaction Policy

Exhibit 99.3 HCW BIOLOGICS INC. RELATED PARTY TRANSACTIONS POLICY (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose HCW Biologics Inc. (collectively with its subsidiaries, the “Company”) is committed to promoting high standards of ethical business conduct and compliance with applicable laws, rules and regulations. As part of this commitmen

May 9, 2025 EX-1.1

Form of Placement Agency Agreement

Exhibit 1.1 FORM OF PLACEMENT AGENCY AGREEMENT May [], 2025 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), HCW Biologics Inc., a Delaware corporation (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of $ of units, each unit consisting of (1) either (i) one

May 9, 2025 EX-FILING FEES

Filing Fees

Exhibit 107 Calculation of Fee Filing Tables Form S-1 (Form Type) HCW Biologics Inc.

May 9, 2025 EX-23.1A

Consent of Independent Registered Public Accounting Firm (Grant Thornton, Predecessor)

EX-23.1A Exhibit 23.1a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2024 (except for Note 16, as to which the date is March 28, 2025), with respect to the financial statements of HCW Biologics Inc. included in the Annual Report on Form 10-K for the year ended December 31, 2024, which are incorporated by reference in this Registration Statement. W

May 9, 2025 EX-10.35

Form of Securities Purchase Agreement

EXHIBIT 10.35 FORM OF SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of [], 2025, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions s

May 9, 2025 EX-99.2

Compensation Committee Charter of the Registrant

Exhibit 99.2 CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to assist the Board in discharging its re

May 9, 2025 EX-4.5

Form of Pre-Funded Common Stock Purchase Warrant

Exhibit 4.5 FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares:      Initial Exercise Date: , 2025 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the

May 9, 2025 EX-10.34

Form of Unsecured Convertible Promissory Note dated May 5, 2025 by and between the Company and the Holder party thereto.

EXHIBIT 10.34 THE SECURITIES REFERENCED HEREIN HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COM

May 9, 2025 EX-4.6

Form of Common Stock Purchase Warrant

Exhibit 4.6 FORM OF COMMON STOCK PURCHASE WARRANT HCW BIOLOGICS INC. Warrant Shares:                          Initial Exercise Date: , 2025 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the da

May 9, 2025 EX-99.1

Audit Committee Charter of the Registrant

Exhibit 99.1 CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Audit Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to: 1.1.1 Oversee the accounting and financial reportin

May 9, 2025 EX-10.33

Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements dated as of May 1, 2025.

EXHIBIT 10.33 HCW BIOLOGICS INC. SECOND AMENDMENT TO AMENDED AND RESTATED SENIOR SECURED NOTE PURCHASE AGREEMENT AND RELATED AGREEMENTS This Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements (this “Second Amendment”) is made as of April , 2025 (the “Effective Date”) by and between HCW Biologics Inc., a Delaware corporation (the “Company”), and e

May 9, 2025 EX-10.36

Form of Lock-Up Agreement

Exhibit 10.36 FORM OF LOCK-UP AGREEMENT , 2025 Re: Securities Purchase Agreement, dated as of , 2025 (the “Purchase Agreement”), between HCW Biologics Inc. (the “Company”) and the purchasers signatory thereto (each, a “Purchaser” and, collectively, the “Purchasers”) Ladies and Gentlemen: Defined terms not otherwise defined in this letter agreement (the “Letter Agreement”) shall have the meanings s

May 1, 2025 LETTER

LETTER

May 1, 2025 Hing Wong Chief Executive Officer HCW Biologics Inc. 2929 N Commerce Parkway Miramar, FL 33025 Re: HCW Biologics Inc. Draft Registration Statement on Form S-1 Submitted April 28, 2025 CIK No. 0001828673 Dear Hing Wong: This is to advise you that we do not intend to review your registration statement. We request that you publicly file your registration statement at least two business da

April 28, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 28, 2025 DRS

Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83

Table of Contents Confidential Treatment Requested by HCW Biologics Inc. Pursuant to 17 C.F.R. Section 200.83 Registration No. 333-      UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter) Delaware 2834 82-5024477 (State or Other Jurisdictio

April 28, 2025 ARS

ARS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40591 HCW Biologics I

April 28, 2025 DEF 14A

BOARD OF DIRECTORS AND CORPORATE GOVERNANCE NOMINATIONS PROCESS AND DIRECTOR QUALIFICATIONS PROPOSAL ONE: DIRECTOR ELECTION PROPOSAL TWO: RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM SECURITY OWNERSHIP OF CERTAIN BENE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 22, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 16, 2025 424B3

Resale of up to $40,000,000 in Shares of Common Stock, up to a total of 7,101,615 Shares of Common Stock

Table of Contents Filed pursuant to Rule 424(b)(3) Registration No. 333-286409 PROSPECTUS Resale of up to $40,000,000 in Shares of Common Stock, and up to a total of 7,101,615 Shares of Common Stock This prospectus relates to the proposed resale by the respective selling stockholders identified below of up to the following respective amounts of shares of our common stock, par value $0.0001 per sha

April 15, 2025 CORRESP

April 15, 2025

April 15, 2025 VIA EDGAR AND E-MAIL Mr. Jason Drory Office of Life Sciences Division of Corporate Finance U.S. Securities and Exchange Commission 100 F. Street, N.E. Washington, DC 20549-7010 Re: HCW Biologics Inc. Registration Statement on Form S-1; Commission File No. 333-286409 Dear Mr. Drory: Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, HCW Biologics Inc. (the

April 14, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events, 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 14, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 8, 2025 LETTER

LETTER

April 8, 2025 Hing Wong Chief Executive Officer HCW Biologics Inc. 2929 N Commerce Parkway Miramar, FL 33025 Re: HCW Biologics Inc. Registration Statement on Form S-1 Filed April 7, 2025 File No. 333-286409 Dear Hing Wong: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind

April 7, 2025 EX-99.2

Compensation Committee Charter of the Registrant

Exhibit 99.2 CHARTER OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to assist the Board in discharging its re

April 7, 2025 EX-FILING FEES

Filing Fees

Exhibit 107 Calculation of Fee Filing Tables Form S-1 (Form Type) HCW Biologics Inc.

April 7, 2025 EX-23.1B

Consent of Independent Registered Public Accounting Firm (Crowe Successor)

EX-23.1b Exhibit 23.1b CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement of HCW Biologics Inc. on Form S-1 of our report dated March 28, 2025 on the balance sheet of HCW Biologics Inc. as of December 31, 2024 and the statements of operations, stockholders’ equity (deficit) and cash flows for the year ended, and to t

April 7, 2025 EX-99.1

Audit Committee Charter of the Registrant

Exhibit 99.1 CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF HCW BIOLOGICS INC. (Adopted and approved on June 10, 2021 and effective as of the Company’s initial public offering) 1. Purpose 1.1 The purpose of the Audit Committee (the “Committee”) of the Board of Directors (the “Board”) of HCW Biologics Inc. (the “Company”) shall be to: 1.1.1 Oversee the accounting and financial reportin

April 7, 2025 S-1

As filed with the Securities and Exchange Commission on April 4, 2025

Table of Contents As filed with the Securities and Exchange Commission on April 4, 2025 Registration No.

April 7, 2025 EX-23.1A

Consent of Independent Register Public Accounting Firm (Grant Thornton, Predecessor)

EX-23.1a Exhibit 23.1a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated May 15, 2024 (except for Note 16, as to which the date is March 28, 2025), with respect to the financial statements of HCW Biologics Inc. included in the Annual Report on Form 10-K for the year ended December 31, 2023, which are incorporated by reference in this Registration Statement. W

April 1, 2025 8-K

Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 01, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 1, 2025 EX-3.1B

Certificate of Correction of the Certificate of Amendment of Certificate of Incorporation, filed April 1, 2025.

Exhibit 3.1b STATE OF DELAWARE CERTIFICATE OF CORRECTION

April 1, 2025 EX-99.1

HCW Biologics Announces 1-for-40 Reverse Stock Split

Exhibit 99.1 HCW Biologics Announces 1-for-40 Reverse Stock Split Miramar, FL – April 1, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related diseases, today announced that its Board of Dir

April 1, 2025 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 01, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 1, 2025 EX-3.1A

Certificate of Amendment of Certificate of Incorporation, filed March 31, 2025.

Exhibit 3.1a STATE OF DELAWARE CERTIFICATE OF AMENDMENT OF CERTIFICATE OF INCORPORATION The corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware does hereby certify: FIRST: That by a unanimous consent in lieu of a special meeting of the Board of Directors of HCW Biologics Inc. resolutions were duly adopted setting forth a proposed amendment

March 28, 2025 EX-10.27

License, Research and Co-Development Agreement with WY Biotech dated November 17, 2024

Exhibit 10.27 LICENSE, RESEARCH, AND CO-DEVELOPMENT AGREEMENT This License, Research, and Co-Development Agreement (this “Agreement”) is made and entered into as of the 17th day of November, 2024 (the “Effective Date”) by and between HCW Biologics Inc., a Delaware corporation with a principal place of business at 2929 North Commerce Parkway, Miramar, Florida 33025 (“Licensor”) and WY Biotech Co.,

March 28, 2025 EX-99.1

HCW Biologics Reports Fourth Quarter and Fiscal Year 2024 Business Highlights and Financial Results

Exhibit 99.1 HCW Biologics Reports Fourth Quarter and Fiscal Year 2024 Business Highlights and Financial Results Miramar, FL – March 28, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related

March 28, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

March 28, 2025 EX-10.28

Letter Agreement for Principal Terms for the Amendment of the License, Research and Co-Development Agreement with WY Biotech dated March 17, 2025 and Company’s Letter to Agree and Accept dated March 19, 2025

Exhibit 10.28 Letter Agreement for Principal Terms for the Amendment of the License, Research and Co-Development Agreement with WY Biotech dated March 17, 2025 and Company’s Letter to Agree and Accept dated March 19, 2025 WY Biotech Co. Ltd. 1115-1118 Tower A No. 500 Yunjin Road Xuhui, Shanghai China HCW Biologics Inc. 2929 North Commerce Parkway Miramar, FL 33025 USA Attn: Dr. Hing Wong, CEO Marc

March 28, 2025 EX-10.35

Definitive Proxy Statement dated February 21, 2025, on Form 14A, including Appendices

Exhibit 10.35 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 AMENDMENT NO. 1 Filed by the Registrant☒ Filed by a Party other than the Registrant☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(

March 28, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40591 HCW Biologics I

March 19, 2025 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

March 6, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 03, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

March 6, 2025 EX-99.1

HCW Biologics Granted Extension by the Nasdaq Hearings Panel to Regain Compliance with Continued Listing Requirements

Exhibit 99.1 HCW Biologics Granted Extension by the Nasdaq Hearings Panel to Regain Compliance with Continued Listing Requirements Miramar, FL – March 6, 2025 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (Nasdaq: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation

February 26, 2025 DEFR14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 AMENDMENT NO. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 AMENDMENT NO. 1 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

February 26, 2025 CT ORDER

CT ORDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION February 26, 2025 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES EXCHANGE ACT OF 1934 HCW Biologics Inc.

February 21, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 20, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

February 21, 2025 EX-10.1

Equity Purchase Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund—Series 4.

Exhibit 10.1 EQUITY PURCHASE AGREEMENT THIS EQUITY PURCHASE AGREEMENT (this “Agreement”) is entered into as of February 20, 2025 (the “Execution Date”), by and between HCW Biologics Inc., a corporation incorporated in the State of Delaware (the “Company”), and Square Gate Capital Master Fund, LLC – Series 4, a series limited liability company organized in the State of Delaware (the “Investor”). RE

February 21, 2025 EX-10.2

Registration Rights Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund—Series 4.

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of February 20, 2025 (the “Execution Date”), is entered into by and between HCW Biologics Inc., a corporation incorporated in the State of Delaware (the “Company”), and Square Gate Capital Master Fund, LLC - Series 4, a series limited liability company organized in the State of Delaware (together

February 21, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defi

February 11, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant  ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

February 7, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 05, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

February 3, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 03, 2025 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

February 3, 2025 EX-99.1

HCW Biologics Granted FDA Clearance to Evaluate One of the Company’s Lead Product Candidates in a First-In- Human Phase 1 Clinical Trial This study will evaluate HCW9302 in patients with moderate to severe alopecia areata

Exhibit 99.1 HCW Biologics Granted FDA Clearance to Evaluate One of the Company’s Lead Product Candidates in a First-In- Human Phase 1 Clinical Trial This study will evaluate HCW9302 in patients with moderate to severe alopecia areata Miramar, FL – February 3, 2025 – HCW Biologics Inc. (“HCWB” or the “Company”) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discov

December 23, 2024 EX-99.1

HCW Biologics Inc. Received NASDAQ Staff Determination Letter Company Expected Notice for Continued Deficiency and Delist Letter from the Nasdaq Stock Market Company Intends to Request Hearing to Appeal in a Timely Manner

EXHIBIT 99.1 HCW Biologics Inc. Received NASDAQ Staff Determination Letter Company Expected Notice for Continued Deficiency and Delist Letter from the Nasdaq Stock Market Company Intends to Request Hearing to Appeal in a Timely Manner Miramar, FL– December 23, 2024 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discover

December 23, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 22, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 20, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 22, 2024 SC 13D/A

HCWB / HCW Biologics Inc. / Wong Hing C - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1 )* HCW BIOLOGICS INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 40423R 105 (CUSIP Number) Hing C Wong, Ph.D. HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 (954) 842-2024 (Name, Address and T

November 20, 2024 424B2

Subject to completion, dated November 20, 2024

Table of Contents Filed pursuant to Rule 424(b)(2) Registration No. 333-266991 The information in this prospectus supplement is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus supplement is not an offer to sell these securities and it is not soliciting an offer to buy

November 20, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 18, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 20, 2024 EX-4.2

Form of Pre-Funded Common Stock Purchase Warrant between the Company and Holder

Exhibit 4.2 FORM OF PRE-FUNDED COMMON STOCK PURCHASE WARRANT HCW Biologics Inc. Warrant Shares: Initial Exercise Date: November , 2024 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after

November 20, 2024 EX-99.2

HCW Biologics and WY Biotech Announce License Agreement for Immunotherapeutic Product Candidate HCW Biologics entered into License, Research and Co-Development Agreement with WY Biotech for one of its new proprietary preclinical molecules HCW Biologi

Exhibit 99.2 HCW Biologics and WY Biotech Announce License Agreement for Immunotherapeutic Product Candidate HCW Biologics entered into License, Research and Co-Development Agreement with WY Biotech for one of its new proprietary preclinical molecules HCW Biologics to receive upfront payment of $7 million and is eligible to receive additional milestone payments and double-digit royalties on future

November 20, 2024 EX-10.1

Placement Agency Agreement, dated November 18, 2024, between the Company and Maxim Group LLC.

Exhibit 10.1 PLACEMENT AGENCY AGREEMENT November 18, 2024 Dr. Hing C. Wong Chief Executive Officer HCW Biologics Inc. 2929 N. Commerce Parkway Miramar, FL 33025 Dear Dr. Wong: This agreement (the “Agreement”) constitutes the agreement between Maxim Group LLC (“Maxim” or the “Placement Agent”) and HCW Biologics Inc., a Delaware corporation (the “Company”), that Maxim shall serve as the exclusive pl

November 20, 2024 EX-10.2

Securities Purchase Agreement, dated November 18, 2024, between the Company and Purchaser

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of November 18, 2024, between HCW Biologics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions s

November 20, 2024 EX-99.1

HCW Biologics Announces Pricing of $6.9 Million Registered Direct Offering and Concurrent Private Placement Priced Above Market Under NASDAQ Rules

Exhibit 99.1 HCW Biologics Announces Pricing of $6.9 Million Registered Direct Offering and Concurrent Private Placement Priced Above Market Under NASDAQ Rules MIRAMAR, Fla., Nov. 18, 2024 (GLOBE NEWSWIRE) - HCW Biologics Inc. (“HCWB” or “HCW Biologics”), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen he

November 20, 2024 EX-4.1

Form of Common Stock Purchase Warrant between the Company and Holder

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

November 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 18, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 14, 2024 EX-10.6

Settlement Agreement and Release, dated July 13, 2024, by and between the Company and Altor BioScience, LLC, NantCell, Inc., and ImmunityBio, Inc.

Exhibit 10.6 CERTAIN INFORMATION HAS BEEN REDACTED FROM THIS EXHIBIT IN ACCORDANCE WITH ITEM 601(B)(10)(IV) OF REGULATION S-K BECAUSE SUCH INFORMATION (1) IS NOT MATERIAL AND (2) IS THE TYPE OF INFORMATION THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. INFORMATION THAT HAS BEEN SO REDACTED FROM THIS EXHIBIT IS MARKED AS FOLLOWS: “XXXXXXXXXX” TO INDICATE THE OMISSION. SETTLEMENT AGREEMENT AND RE

November 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

F UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW

November 14, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

November 14, 2024 EX-99.1

HCW Biologics Reports Third Quarter 2024 Financial Results and Business Highlights

Exhibit 99.1 HCW Biologics Reports Third Quarter 2024 Financial Results and Business Highlights Miramar, FL– November 14, 2024 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and age-related diseases, today

November 14, 2024 EX-10.5

Form of First Amendment to the Amended and Restated Senior Secured Note Purchase Agreement, dated September 30, 2024, by and between the Company and Purchaser parties thereto

Exhibit 10.5 HCW BIOLOGICS INC. FIRST AMENDMENT TO AmendED AND RESTATED SENIOR SECURED NOTE PURCHASE AGREEMENT This First Amendment to Amended and Restated Senior Secured Note Purchase Agreement(this “Amendment”) is made as of September 30, 2024 (the “Effective Date”) by and between HCW Biologics Inc., a Delaware corporation (the “Company”), and each of the purchasers listed on Exhibit B attached

September 20, 2024 EX-16.1

Letter from Grant Thornton dated September 20, 2024.

Exhibit 16.1 Submitted on Letterhead for Grant Thornton LLP 801 Brickell Ave., Suite 2450 Miami, FL33131-4943 September 20, 2024 U.S. Securities and Exchange Commission Office of the Chief Accountant 100 F Street, NE Washington, DC 20549 Re: HCW Biologics Inc. File No. 001-40591 Dear Sir or Madam: We have read Item 4.01 of Form 8-K of HCW Biologics Inc. dated September 20, 2024, and agree with the

September 20, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 20, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission F

August 23, 2024 8-K/A

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission Fi

August 23, 2024 EX-99.1

HCW Biologics Reports Second Quarter 2024 Financial Results and Business Highlights

Exhibit 99.1 HCW Biologics Reports Second Quarter 2024 Financial Results and Business Highlights Correction This release has made a correction to a release issued under the same headline on August 14, 2024, by HCW Biologics, Inc. (NASDAQ: HCWB), to show the amount included in the condensed interim balance sheet for Cash and cash equivalents as of December 31, 2023 as $3,595,101, not $95,101 as pre

August 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

F UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW Biol

August 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

August 14, 2024 EX-10.4

Form of Escrow Agreement, dated July 2, 2024, by and among the Company, Escrow Agent and Noteholder parties thereto

Exhibit 10.4 AMENDED AND RESTATED ESCROW AGREEMENT THIS AMENDED AND RESTATED ESCROW AGREEMENT dated as of July 2, 2024 (as the same may be amended, supplemented and/or otherwise modified from time to time, the “Escrow Agreement”), is made and entered into by and among the Noteholders listed on “Exhibit A” attached to this Escrow Agreement as secured parties as such Exhibit may be amended from time

August 14, 2024 EX-10.2

Form of Senior Secured Promissory Note by and between the Company and the Holder party thereof

Exhibit 10.2 THE SECURITIES REFERENCED HEREIN HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMP

August 14, 2024 EX-10.1

Form of Amended and Restated Senior Secured Note Purchase Agreement, dated July 2, 2024, by and between the Company and the Purchaser party thereto

Exhibit 10.1 HCW BIOLOGICS INC. AmendED AND RESTATED SENIOR SECURED NOTE PURCHASE AGREEMENT This Amended and Restated Senior Secured Note Purchase Agreement (this “Agreement”) is made as of July 2, 2024 (the “Closing Date”) by and between HCW Biologics Inc., a Delaware corporation (the “Company”), and each of the purchasers listed on Exhibit B attached to this Agreement (each a “Purchaser” and tog

August 14, 2024 EX-99.1

HCW Biologics Reports Second Quarter 2024 Financial Results and Business Highlights

Exhibit 99.1 HCW Biologics Reports Second Quarter 2024 Financial Results and Business Highlights Miramar, FL– August 14, 2024 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and age-related diseases, today

August 14, 2024 EX-10.3

Form of Amended and Restated Pledge Agreement, dated July 2, 2024, by and among the Company, Escrow Agent and Noteholder parties thereto

Exhibit 10.3 AMENDED AND RESTATED PLEDGE AGREEMENT This AMENDED AND RESTATED PLEDGE AGREEMENT, dated as of July 2, 2024 (as the same may be amended, supplemented and/or otherwise modified from time to time, this “Agreement”), is entered into by and between HCW BIOLOGICS INC., a Delaware Corporation (“Grantor”), Mercedes M. Sellek, P.A., a Florida corporation (together with its assigns, the “Escrow

August 12, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 06, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

July 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 20, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 17, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

June 17, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File N

May 20, 2024 ARS/A

ARS/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-4

May 15, 2024 EX-99.1

HCW Biologics Reports First Quarter 2024 Financial Results and Business Highlights

Exhibit 99.1 HCW Biologics Reports First Quarter 2024 Financial Results and Business Highlights Miramar, FL – May 15, 2024 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and age-related diseases, today rep

May 15, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 15, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A (Amendment No. 1) (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-4

May 15, 2024 EX-10.5

Form of Subscription Agreement, dated February 20, 2024, by and between the Company and the Subscribers party thereto

Exhibit 10.5 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE AND CONFIDENTIAL. FORM OF COMMON STOCK SUBSCRIPTION AGREEMENT THIS COMMON STOCK SUBSCRIPTION AGREEMENT (this "Agreement") is made as of the date set forth on the signature page hereof between HCW BIOLOGICS INC.,

May 15, 2024 EX-10.1

Senior Secured Note Purchase Agreement, dated March 28, 2024, by and between the Company and the Purchaser party thereto

4131-2309-9215.4 EXHIBIT 10.1 HCW BIOLOGICS INC. SENIOR SECURED NOTE PURCHASE AGREEMENT This Senior Secured Note Purchase Agreement (this “Agreement”) is made as of March 28, 2024 (the “Closing Date”) by and between HCW Biologics Inc., a Delaware corporation (the “Company”), and each of the purchasers listed on Exhibit B attached to this Agreement (each a “Purchaser” and together the “Purchasers”)

May 15, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40591 HCW Biolo

May 3, 2024 8-K

Non-Reliance on Previously Issued Financial Statements or a Related Audit Report or Completed Interim Review

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 03, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File Nu

May 1, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 HCW Biologics Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40591 82-5024477 (State or Other Jurisdiction of Incorporation) (Commission File

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

How Much do you Like Fintel?
Please share your opinion of our service!
Excellent Bad
Fintel data has been cited in the following publications:
Daily Mail Fox Business Business Insider Wall Street Journal The Washington Post Bloomberg Financial Times Globe and Mail
NASDAQ.com Reuters The Guardian Associated Press FactCheck.org Snopes Politifact
Federal Register The Intercept Forbes Fortune Magazine TheStreet Time Magazine Canadian Broadcasting Corporation International Business Times
Cambridge University Press Investopedia MarketWatch NY Daily News Entrepreneur Newsweek Barron's El Economista