OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership109,543 shares
Latest Disclosed Value $ 124,879
Renaissance Technologies Llc ownership in OPK / OPKO Health, Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 109,543 shares of OPKO Health, Inc. (MX:OPK) valued at $124,879 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 0 shares of OPKO Health, Inc..

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F OPKO HEALTH COM 68375N103 109,543 109,543 125 0.0002
2026-02-12 2025-12-31 13F OPKO HEALTH COM 68375N103 0 -59,700 -100.00 0 -100.00
2025-11-13 2025-09-30 13F OPKO HEALTH COM 68375N103 59,700 21,600 56.69 93 84.00 0.0001
2025-08-13 2025-06-30 13F OPKO HEALTH COM 68375N103 38,100 38,100 50 0.0001
2025-05-14 2025-03-31 13F OPKO HEALTH COM 68375N103 0 -145,977 -100.00 0 -100.00
2025-02-13 2024-12-31 13F OPKO HEALTH COM 68375N103 145,977 -312,950 -68.19 215 -68.67 0.0003
2024-11-13 2024-09-30 13F OPKO HEALTH COM 68375N103 458,927 174,184 61.17 684 92.39 0.0010
2024-08-09 2024-06-30 13F OPKO HEALTH COM 68375N103 284,743 -1,093,453 -79.34 356 35,400.00 0.0006
2024-05-13 2024-03-31 13F OPKO HEALTH COM 68375N103 1,378,196 1,378,196 2 0.0026
2024-02-13 2023-12-31 13F OPKO HEALTH COM 68375N103 0 -808,643 -100.00 0 -100.00
2023-11-14 2023-09-30 13F OPKO HEALTH COM 68375N103 808,643 487,290 151.64 1 0.0022
2023-08-11 2023-06-30 13F OPKO HEALTH COM 68375N103 321,353 -1,366,790 -80.96 1 -100.00 0.0010
2023-05-12 2023-03-31 13F OPKO HEALTH COM 68375N103 1,688,143 -598,400 -26.17 2 0.00 0.0033
2023-02-13 2022-12-31 13F OPKO HEALTH COM 68375N103 2,286,543 -549,800 -19.38 3 -99.96 0.0039
2022-11-14 2022-09-30 13F OPKO HEALTH COM 68375N103 2,836,343 -1,053,829 -27.09 5,361 -45.53 0.0076
2022-08-12 2022-06-30 13F OPKO HEALTH COM 68375N103 3,890,172 3,480,129 848.72 9,842 597.52 0.0117
2022-05-13 2022-03-31 13F OPKO HEALTH COM 68375N103 410,043 410,043 1,411 0.0017
2022-02-11 2021-12-31 13F OPKO HEALTH COM 68375N103 0 -910,153 -100.00 0 -100.00
2021-11-12 2021-09-30 13F OPKO HEALTH COM 68375N103 910,153 -329,790 -26.60 3,322 -33.85 0.0043
2021-08-13 2021-06-30 13F OPKO HEALTH COM 68375N103 1,239,943 1,239,943 5,022 0.0063
2021-05-13 2021-03-31 13F OPKO HEALTH COM 68375N103 0 -594,343 -100.00 0 -100.00
2021-02-10 2020-12-31 13F OPKO HEALTH COM 68375N103 594,343 594,343 2,348 0.0025
2019-02-12 2018-12-31 13F OPKO HEALTH COM 68375N103 0 -29,043 -100.00 0 -100.00
2018-11-13 2018-09-30 13F OPKO HEALTH COM 68375N103 29,043 -341,358 -92.16 100 -91.48 0.0001
2018-08-13 2018-06-30 13F OPKO HEALTH COM 68375N103 370,401 0 0.00 1,174 0.00 0.0013
2018-05-14 2018-03-31 13F OPKO HEALTH COM 68375N103 370,401 210,410 131.51 1,174 49.74 0.0013
2018-02-13 2017-12-31 13F OPKO HEALTH COM 68375N103 159,991 -917,500 -85.15 784 -89.39 0.0009
2017-11-13 2017-09-30 13F OPKO HEALTH COM 68375N103 1,077,491 -538,200 -33.31 7,392 -30.47 0.0087
2017-08-11 2017-06-30 13F OPKO HEALTH COM 68375N103 1,615,691 1,615,691 49.95 10,631 43.82 0.0136
2017-02-13 2016-12-31 13F OPKO HEALTH COM 68375N103 0 -1,412,757 -100.00 0 -100.00
2016-11-14 2016-09-30 13F OPKO HEALTH COM 68375N103 1,412,757 1,412,757 0.00 14,961 0.0264
2016-02-11 2015-12-31 13F OPKO HEALTH COM 68375N103 0 0 0 0.0000
2015-11-12 2015-09-30 13F OPKO HEALTH COM 68375N103 0 -1,907,498 -100.00 0 -100.00
2015-08-14 2015-06-30 13F OPKO HEALTH COM 68375N103 1,907,498 654,100 52.19 30,673 72.70 0.0699
2015-05-13 2015-03-31 13F OPKO HEALTH COM 68375N103 1,253,398 1,253,398 -34.29 17,761 -42.10 0.0378
2014-02-14 2013-12-31 13F OPKO HEALTH COM 68375N103 0 -17,802 -100.00 0 -100.00
2013-11-13 2013-09-30 13F OPKO HEALTH COM 68375N103 17,802 17,802 157 0.0004
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.