Spruce Biosciences, Inc.
US ˙ OTCPK ˙ US85209E1091
BU SEMBOL ARTIK AKTİF DEĞİL

SecuritySPRBD / Spruce Biosciences, Inc.
InstitutionMorgan Stanley
Latest Disclosed Ownership1,415 shares
Latest Disclosed Value $ 92,471
Morgan Stanley reports 264.69% increase in ownership of SPRBD / Spruce Biosciences, Inc.

On May 15, 2026 - Morgan Stanley filed a 13F-HR form disclosing ownership of 1,415 shares of Spruce Biosciences, Inc. (US:SPRBD) valued at $92,471 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on May 27, 2026 disclosing 388 shares of Spruce Biosciences, Inc.. This represents a change in shares of 264.69% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F SPRUCE BIOSCIENCES COM NEW 85209E208 1,415 1,027 264.69 92 178.79 0.0000
2026-05-27 2025-12-31 13F/A-1 SPRUCE BIOSCIENCES COM NEW 85209E208 388 290 295.92 34 0.0000
2026-02-13 2025-12-31 13F SPRUCE BIOSCIENCES COM NEW 85209E208 388 290 34 0.0000
2026-05-27 2025-09-30 13F/A-1 SPRUCE BIOSCIENCES COM NEW 85209E208 98 98 1 0.0000
2025-11-14 2025-09-30 13F SPRUCE BIOSCIENCES COM NEW 85209E208 98 98 1 0.0000
2025-08-15 2025-06-30 13F SPRUCE BIOSCIENCES COM 85209E109 0 -7,396 -100.00 0 -100.00
2025-05-15 2025-03-31 13F SPRUCE BIOSCIENCES COM 85209E109 7,396 5,263 246.74 2 0.0000
2025-05-15 2024-12-31 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 2,133 0 0.00 1 -100.00 0.0000
2025-02-14 2024-12-31 13F SPRUCE BIOSCIENCES COM 85209E109 2,133 0 1 0.0000
2025-05-14 2024-09-30 13F/A-2 SPRUCE BIOSCIENCES COM 85209E109 2,133 0 0.00 1 0.00 0.0000
2025-02-14 2024-09-30 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 2,133 0 1 0.0000
2024-11-14 2024-09-30 13F SPRUCE BIOSCIENCES COM 85209E109 2,133 0 1 0.0000
2025-05-14 2024-06-30 13F/A-2 SPRUCE BIOSCIENCES COM 85209E109 2,133 -19,390 -90.09 1 -93.75 0.0000
2024-10-17 2024-06-30 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 2,133 -19,390 1 0.0000
2024-08-14 2024-06-30 13F SPRUCE BIOSCIENCES COM 85209E109 2,133 -19,390 1 0.0000
2024-10-17 2024-03-31 13F/A-2 SPRUCE BIOSCIENCES COM 85209E109 21,523 19,390 909.05 17 166.67 0.0000
2024-08-16 2024-03-31 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 21,523 19,390 17 0.0000
2024-05-15 2024-03-31 13F SPRUCE BIOSCIENCES COM 85209E109 21,523 19,390 17 0.0000
2024-08-16 2023-12-31 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 2,133 2 0.09 6 50.00 0.0000
2024-02-13 2023-12-31 13F SPRUCE BIOSCIENCES COM 85209E109 2,133 2 6 0.0000
2023-11-15 2023-09-30 13F SPRUCE BIOSCIENCES COM 85209E109 2,131 0 0.00 5 0.00 0.0000
2023-08-14 2023-06-30 13F SPRUCE BIOSCIENCES COM 85209E109 2,131 -1,019 -32.35 5 -33.33 0.0000
2023-05-15 2023-03-31 13F SPRUCE BIOSCIENCES COM 85209E109 3,150 -189 -5.66 7 100.00 0.0000
2023-02-14 2022-12-31 13F SPRUCE BIOSCIENCES COM 85209E109 3,339 -19,835 -85.59 4 -90.32 0.0000
2022-11-14 2022-09-30 13F SPRUCE BIOSCIENCES COM 85209E109 23,174 -37,486 -61.80 31 -70.75 0.0000
2022-10-27 2022-06-30 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 60,660 49,239 431.13 106 381.82 0.0000
2022-08-15 2022-06-30 13F SPRUCE BIOSCIENCES COM 85209E109 60,660 49,239 106 0.0000
2022-10-27 2022-03-31 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 11,421 -970 -7.83 22 -60.00 0.0000
2022-05-13 2022-03-31 13F SPRUCE BIOSCIENCES COM 85209E109 11,421 -970 22 0.0000
2022-02-14 2021-12-31 13F SPRUCE BIOSCIENCES COM 85209E109 12,391 -63,520 -83.68 55 -87.94 0.0000
2021-11-15 2021-09-30 13F SPRUCE BIOSCIENCES COM 85209E109 75,911 -46,679 -38.08 456 -66.84 0.0001
2021-08-23 2021-06-30 13F/A-1 SPRUCE BIOSCIENCES COM 85209E109 122,590 88,298 257.49 1,375 141.65 0.0002
2021-08-16 2021-06-30 13F SPRUCE BIOSCIENCES COM 85209E109 122,590 88,298 1,375 0.0000
2021-05-17 2021-03-31 13F SPRUCE BIOSCIENCES COM 85209E109 34,292 28,963 543.50 569 341.09 0.0001
2021-02-16 2020-12-31 13F SPRUCE BIOSCIENCES COM 85209E109 5,329 5,329 129 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.